Fig. 7From: Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biologyPlot of regression equation of Best Disease Severity Index (BDSI) versus modulus of relative energy of dimerization |ΔΔEdim| of variant BEST1 subunits: BDSI = 0.24935 · |ΔΔEdim| + 6.56527, Eq. (6). BDSI was derived from clinically evaluated BCVA (best-corrected visual acuity in logMAR scale) and age of 27 probands, Eq. (5), Table 2; ΔΔEdim was computed by molecular mechanics from the 3D model of human CaCC. Statistical parameters of the correlation: number of available data points: n = 20, squared correlation coefficient: R2 = 0.854, leave-one-out cross-validated correlation coefficient: \({\text{R}}^{ 2}_{\text{xv}}\) = 0.827, Fischer F-test: F = 76.164, significance of correlation: α > 95%, number of outliers removed: no = 5Back to article page