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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology

Fig. 5

(figure adapted from: Ref. [10])

Subunits C and E of the X-ray structure of chicken bestrophin-1 (in ribbon representation) forming part of the calcium-activated chloride channel [9, 10]. The axial cross-section of the ion pore (yellow tube) shows the approximate size and shape of the pore and indicates the positions of the pore neck and aperture as well as calcium binding sites involved in channel gating. Boundaries of the cell membrane are indicated by the horizontal red lines

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