Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

Table 4 Correlations of peroxiredoxins (protein amount) and clinical features

	Age (months)	Onset pattern: 1 (early); 2 (regressive); 3 (mixed)	Brief non verbal IQ*	ADOS score**	CARS total score	CARS Activity Level item score	CARS body use (sterotypes) item score	CARS verbal communication item score	Non verbal communication Item score	CARS total number of items whose score was ≥ 3	Prx2/IgG in plasma	Prx5/IgG in plasma
Prx2/actin in RBC	NS	NS	NS	NS	p = 0.027 r = − 0.47 pFDR = 0.13	p = 0.0043 r = − 0.58 pFDR = 0.13	NS	NS	p = 0.020 r = − 0.49 pFDR = 0.12	p = 0.01 r = − 0.5 pFDR = 0.15	NS	p = 0.0048 r = 0.59 pFDR = 0.01
Prx2/IgG in plasma	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS		NS
Prx5/IgG in plasma	NS	NS	NS	p = 0.021 r = − 0.5 pFDR = 0.16	NS	NS	NS	NS	NS	p = 0.022 r = − 0.5 pFDR = 0.13

RBC red blood cell, Prx peroxiredoxin, IgG immunoglobulin G, ADOS Autism Diagnostic Observation Schedule, CARS Childhood Autism Rating Scale
*Cognitive level: ≥ 70, normal; 50-69, mild cognitive impairment; 35-49, moderate cognitive impairment; < 35, severe cognitive impairment [55]
**ADOS modules 1 or 2 (Total score Autism cut off = 12)

ISSN: 1479-5876