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Table 4 Correlations of peroxiredoxins (protein amount) and clinical features

From: Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

  Age (months) Onset pattern: 1 (early); 2 (regressive); 3 (mixed) Brief non verbal IQ* ADOS score** CARS total score CARS Activity Level item score CARS body use (sterotypes) item score CARS verbal communication item score Non verbal communication Item score CARS total number of items whose score was ≥ 3 Prx2/IgG in plasma Prx5/IgG in plasma
Prx2/actin in RBC NS NS NS NS p = 0.027
r = − 0.47
pFDR = 0.13
p = 0.0043
r = − 0.58
pFDR = 0.13
NS NS p = 0.020
r = − 0.49
pFDR = 0.12
p = 0.01
r = − 0.5
pFDR = 0.15
NS p = 0.0048
r = 0.59
pFDR = 0.01
Prx2/IgG in plasma NS NS NS NS NS NS NS NS NS NS   NS
Prx5/IgG in plasma NS NS NS p = 0.021
r = − 0.5
pFDR = 0.16
NS NS NS NS NS p = 0.022
r = − 0.5
pFDR = 0.13
  
  1. RBC red blood cell, Prx peroxiredoxin, IgG immunoglobulin G, ADOS Autism Diagnostic Observation Schedule, CARS Childhood Autism Rating Scale
  2. *Cognitive level: ≥ 70, normal; 50-69, mild cognitive impairment; 35-49, moderate cognitive impairment; < 35, severe cognitive impairment [55]
  3. **ADOS modules 1 or 2 (Total score Autism cut off = 12)