Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

Table 3 Correlations between gene expression of cytokines and inflammation/oxidation-related molecules

Cytokine or inflammation-related molecules	AHR	HSP70i	IL6	IL10	IL12A	IL1 beta	COX2	PRX5	STAT3	TNF-alpha
AHR				p = 0.0014 r = 0.75 pFDR = 0.031		p = 0.0265 r = 0.56 pFDR = 0.159	p = 0.0458 r = 0.51 pFDR = 0.178	p = 0.0281 r = − 0.55 pFDR = 0.154	p = 0.0027 r = 0.70 pFDR = 0.036	p = 0.0417 r = 0.51 pFDR = 0.183
HSP70i			p = 0.0176 r = − 0.58 pFDR = 0.129		p = 0.0161 r = − 0.59 pFDR = 0.132
IL6					p = 0.0079 r = 0.64 pFDR = 0.075
IL10	p = 0.0112 r = 0.44 pFDR = 0.082		p = 0.0484 r = 0.35 pFDR = 0.213			p = 0.0012 r = 0.73 pFDR = 0.040				p = 0.0010 r = 0.74 pFDR = 0.066
IL12A		p = 0.0346 r = − 0,37 pFDR = 0.19	p < 0.0001 r = 0.63 pFDR = 0.003	p = 0.0049 r = 0.48 pFDR = 0.064		p = 0.0059 r = 0.65 pFDR = 0.065
IL1 beta		p = 0.006 r = − 0.47 pFDR = 0.057	p = 0.0053 r = 0.47 pFDR = 0.058							p = 0.0015 r = 0.73 pFDR = 0.025
COX1									p = 0.0420 r = 0.65 pFDR = 0.173
COX2								p = 0.0320 r = − 0.69 pFDR = 0.162
PRX2
PRX5		p = 0.0368 r = − 0.36 pFDR = 0.187					p = 0.0014 r = − 0.53 pFDR = 0.023		p = 0.0386 r = − 0.52 pFDR = 0.182
STAT3	p < 0.0001 r = 0.69 pFDR = 0.007			p = 0.0176 r = 0.41 pFDR = 0.116			p = 0.0484 r = 0.35 pFDR = 0.213	p = 0.0221 r = − 0.40 pFDR = 0.133		p = 0.0196 r = 0.58 pFDR = 0.129
TNF-alpha	p = 0.0194 r = 0.40 pFDR = 0.128	p = 0.0435 r = − 0.35 pFDR = 0.205		p = 0.0002 r = 0.60 pFDR = 0.004					p = 0.0092 r = 0.45 pFDR = 0.076

Significant correlations (p ≤ 0.05) are shown. Correlations found in ASD children alone are shown in underline; correlations found in the whole population (ASD and TD children) are shown in italic

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