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Table 2 Univariate and multivariate analyses of OS and BCSS for the MBC variables included in the study before PSM

From: The role of radiotherapy in metaplastic breast cancer: a propensity score-matched analysis of the SEER database

Characteristics Univariate Multivariate
OS BCSS OS BCSS
HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value HR (95% CI) P-value
Age at diagnosis (< 60 as ref.)
 ≥ 60 1.92 (1.63–2.26) < 0.01 1.23 (1.02–1.48) <0.05 1.81 (1.51–2.16) < 0.01 1.36 (1.11–1.66) < 0.001
Race (white as ref.)
 Black 1.02 (0.82–1.27) 0.843 1.12 (0.88–1.43) 0.364 1.01 (0.81–1.26) 0.958 0.97 (0.76–1.25) 0.828
 Others 0.91 (0.65–1.26) 0.583 0.98 (0.68–1.42) 0.922 0.95 (0.69–1.32) 0.763 0.97 (0.67–1.41) 0.872
Marital status (single as ref.)
 Married 0.92 (0.74–1.14) 0.449 0.78 (0.62–1.00) < 0.05 0.93 (0.74–1.17) 0.54 0.92 (0.71–1.18) 0.506
Grade (G1 as ref.)
 G2 1.23 (0.79–1.93) 0.36 1.08 (0.61–1.92) 0.786 1.08 (0.69–1.69) 0.747 0.93 (0.52–1.65) 0.801
 G3 1.5 (1.01–2.25) < 0.05 1.77 (1.07–2.92) < 0.05 1.18 (0.78–1.77) 0.438 1.14 (0.69–1.9) 0.605
 G4 1.94 (1.20–3.15) < 0.01 2.50 (1.40–4.49) < 0.01 1.56 (0.96–2.54) 0.076 1.65 (0.92–2.98) 0.095
ER status (negative as ref.)
 Positive 0.9 (0.73–1.12) 0.36 0.88 (0.68–1.13) 0.318 0.88 (0.68–1.14) 0.316 0.8 (0.59–1.08) 0.146
PR status (negative as ref.)
 Positive 0.8 (0.62–1.03) 0.077 0.87 (0.66–1.16) 0.339 0.81 (0.60–1.09) 0.162 0.95 (0.68–1.34) 0.779
Stage T (≤ 5 cm as ref.)
 > 5 cm 3.65 (3.11–4.28) < 0.01 4.55 (3.79–5.46) <  0.001 2.92 (2.44–3.49) < 0.01 3.44 (2.79–4.24) < 0.001
Stage N (N0 as ref.)
 N1 1.79 (1.48–2.17) < 0.01 2.35 (1.89–2.91) <  0.001 1.55 (1.26–1.91) < 0.01 1.78 (1.41–2.25) < 0.001
 N2 3.45 (2.60–4.59) < 0.01 4.01 (2.91–5.52) <  0.001 2.55 (1.88–3.46) < 0.01 2.49 (1.76–3.51) < 0.001
 N3 3.86 (2.78–5.36) < 0.01 5.03 (3.54–7.17) <  0.001 2.91 (2.06–4.11) < 0.01 3.33 (2.29–4.84) < 0.001
Breast operation (lumpectomy as ref.)
 Mastectomy 2.56 (2.14–3.06) < 0.01 2.75 (2.22–3.41) <  0.001 1.3 (1.05–1.61) < 0.05 1.32 (1.02–1.70) < 0.05
Chemotherapy (not done/unknown as ref.)
 Done 0.62 (0.53–0.72) < 0.01 0.99 (0.82–1.2) 0.934 0.71 (0.60–0.85) < 0.001 1.02 (0.82–1.27) 0.848
Radiotherapy (not done as ref.)
 Done 0.62 (0.53–0.73) < 0.001 0.73 (0.61–0.88) < 0.001 0.73 (0.61–0.88) 0.001 0.71 (0.58–0.88) < 0.01
Axilla LN operation (SLNB as ref.)
 ALND 1.91 (1.62–2.25) < 0.001 2.18 (1.79–2.65) < 0.001 1.17 (0.97–1.42) 0.096 1.14 (0.91–1.43) 0.254
  1. SLNB Sentinel lymph node biopsy, ALND axillary lymph node dissection
  2. Significant results are in italic