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Table 1 Methylation-driven mRNAs

From: Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers

mRNA Normal mean Tumor mean logFC P Value Adjusted-P Cor Cor P-value
ECSCR 0.651549745 0.777875207 0.255663395 6.97E−21 1.03E−18 − 0.401694346 1.85E−19
TBX4 0.3491894 0.503087408 0.526799315 7.58E−21 1.12E−18 − 0.353891186 3.64E−15
TIE1 0.559830867 0.675047137 0.269997212 1.21E−20 1.79E−18 − 0.406629901 6.08E−20
NEFH 0.254444122 0.435542374 0.775464224 1.40E−20 2.07E−18 − 0.321798888 1.16E−12
ACVRL1 0.398975345 0.517535129 0.375357195 3.26E−20 4.82E−18 − 0.386877674 4.73E−18
USHBP1 0.419199887 0.525059456 0.324842471 3.63E−20 5.37E−18 − 0.323007247 9.42E−13
ERN2 0.264647925 0.387648278 0.550673914 3.92E−20 5.80E−18 − 0.450728621 1.20E−24
COX7A1 0.560388444 0.666059579 0.249224026 9.41E−20 1.39E−17 − 0.342569242 3.00E−14
SULT1C4 0.176980042 0.3113128 0.814778224 2.45E−19 3.62E−17 − 0.375338318 5.28E−17
ART4 0.531234199 0.652680788 0.297029548 2.53E−19 3.75E−17 − 0.425340294 7.44E−22
HIST1H3E 0.313889479 0.456138176 0.539214244 1.45E−18 2.15E−16 − 0.390470196 2.19E−18
ZNF492 0.077650427 0.196364234 1.33846642 1.18E−17 1.75E−15 − 0.378866342 2.55E−17
ZNF728 0.138731042 0.290955121 1.068506001 1.32E−17 1.95E−15 − 0.346356662 1.50E−14
S1PR1 0.33644215 0.424456445 0.33525806 4.34E−17 6.43E−15 − 0.375495078 5.11E−17
MUC13 0.657841786 0.551979674 − 0.253125507 4.44E−17 6.57E−15 − 0.402604202 1.51E−19
CCDC8 0.360671572 0.480500959 0.413853596 8.99E−17 1.33E−14 − 0.389064482 2.96E−18
ZNF578 0.281145557 0.394615614 0.489130794 1.12E−16 1.66E−14 − 0.459621578 1.11E−25
FES 0.424918825 0.49946057 0.233183531 2.74E−16 4.05E−14 − 0.370960412 1.29E−16
ASCL1 0.096716299 0.200703748 1.053236604 2.98E−16 4.41E−14 − 0.331763879 2.08E−13
ALG1L 0.461379719 0.287062126 − 0.684591589 3.14E−16 4.65E−14 − 0.466908378 1.49E−26
ELF3 0.462412193 0.359973363 − 0.361289285 4.47E−16 6.61E−14 − 0.45067724 1.22E−24
TMEM88 0.583625618 0.738189625 0.338948249 7.89E−16 1.17E−13 − 0.390308898 2.27E−18
GSTM5 0.356896303 0.481942079 0.433354815 1.13E−15 1.68E−13 − 0.353462769 3.95E−15
IRX1 0.098629887 0.220552417 1.161024783 1.21E−15 1.79E−13 − 0.344157687 2.24E−14
ZNF454 0.183616121 0.338501411 0.88246912 1.44E−15 2.13E−13 − 0.602235321 3.13E−47
TK2 0.615291641 0.702921916 0.192094042 1.71E−15 2.52E−13 − 0.365352213 3.94E−16
ZSCAN1 0.289768404 0.400355348 0.466380783 2.83E−15 4.19E−13 − 0.397488998 4.73E−19
ZNF677 0.220497196 0.315626597 0.517458471 2.86E−15 4.23E−13 − 0.527352048 1.21E−34
ZNF582 0.130372053 0.239679107 0.878469505 5.74E−15 8.49E−13 − 0.558968642 1.43E−39
DAPP1 0.510432574 0.394016678 − 0.373463704 1.29E−14 1.91E−12 − 0.490584559 1.57E−29
SRPX2 0.600591335 0.480798168 − 0.32095226 1.42E−14 2.10E−12 − 0.383430149 9.83E−18
CCDC181 0.283605585 0.41823899 0.560441617 3.23E−14 4.78E−12 − 0.319044754 1.84E−12
SULT4A1 0.24652482 0.348099193 0.497765567 7.69E−14 1.14E−11 − 0.358208198 1.59E−15
LRRC4 0.321370351 0.418618502 0.38139924 1.26E−13 1.87E−11 − 0.421045183 2.10E−21
ZSCAN23 0.12251013 0.209336095 0.772920046 1.57E−13 2.32E−11 − 0.362584137 6.80E−16
F2RL1 0.242790645 0.208656331 − 0.218584138 1.74E−13 2.57E−11 − 0.35941342 1.26E−15
ZNF334 0.17466699 0.256829933 0.556206371 2.31E−13 3.43E−11 − 0.459451082 1.16E−25
ZNF471 0.130738051 0.279080546 1.094002465 5.46E−13 8.07E−11 − 0.548011494 8.37E−38
HOXB2 0.34354942 0.513088034 0.578688733 6.70E−13 9.91E−11 − 0.491155695 1.32E−29
PRR19 0.666407262 0.728756031 0.129031796 9.23E−13 1.37E−10 − 0.420836129 2.20E−21
AGR2 0.669953934 0.554274136 − 0.273462209 1.68E−12 2.49E−10 − 0.51205684 1.93E−32
NQO1 0.702158099 0.525979398 − 0.416789616 2.08E−12 3.08E−10 − 0.425444078 7.26E−22
GIPC2 0.179310415 0.281572165 0.651045433 3.52E−12 5.21E−10 − 0.36721046 2.73E−16
OXT 0.553265288 0.656785573 0.247451026 4.61E−12 6.83E−10 − 0.519344744 1.77E−33
B3GALT2 0.534256964 0.658626901 0.301927631 6.78E−12 1.00E−09 − 0.477778193 6.83E−28
EFS 0.197613625 0.297157242 0.588544115 1.42E−11 2.10E−09 − 0.391422631 1.78E−18
RAB34 0.295528869 0.254270265 − 0.21693631 2.05E−11 3.03E−09 − 0.424411453 9.32E−22
ACTRT3 0.391186063 0.353188058 − 0.147418408 5.54E−11 8.21E−09 − 0.329154572 3.27E−13
CLDN8 0.727830255 0.618464903 − 0.234910297 9.70E−11 1.44E−08 − 0.328690081 3.55E−13
AQP1 0.366569984 0.501482299 0.452110121 2.34E−10 3.46E−08 − 0.597245937 2.74E−46
SP8 0.202841356 0.297916967 0.554558466 2.69E−10 3.98E−08 − 0.317009628 2.58E−12
HORMAD2 0.350476203 0.461146819 0.395909658 3.14E−10 4.65E−08 − 0.457907737 1.76E−25
GALM 0.255948625 0.226747119 − 0.174770041 6.86E−10 1.02E−07 − 0.356239606 2.33E−15
RABGGTB 0.47835678 0.385164319 − 0.312612985 6.89E−10 1.02E−07 − 0.3330019 1.67E−13
KCNE3 0.256671142 0.314316199 0.292295525 7.52E−10 1.11E−07 − 0.350037722 7.53E−15
ZNF879 0.147629821 0.2000367 0.438280535 1.01E−09 1.50E−07 − 0.453856587 5.23E−25
ZNF257 0.157589016 0.245609973 0.640202155 1.28E−09 1.89E−07 − 0.359120932 1.34E−15
ZNF382 0.101492 0.295488981 1.541738316 1.35E−09 1.99E−07 − 0.391566521 1.73E−18
GSTM1 0.156396431 0.253910031 0.699109797 2.76E−09 4.08E−07 − 0.563212162 2.84E−40
PLAU 0.62150196 0.702145935 0.176011973 4.00E−09 5.92E−07 − 0.570934425 1.41E−41
PIGR 0.667952501 0.708575582 0.085176236 5.52E−09 8.16E−07 − 0.658618149 3.68E−59
CFTR 0.282943087 0.394972666 0.481240926 9.95E−09 1.47E−06 − 0.42150843 1.88E−21
SPDYC 0.704147468 0.724837107 0.041779213 1.76E−08 2.60E−06 − 0.47588325 1.18E−27
ZNF418 0.242511045 0.347906619 0.520649675 2.19E−08 3.23E−06 − 0.60435923 1.23E−47
KLHDC9 0.218223326 0.21602453 − 0.014610182 2.63E−08 3.90E−06 − 0.324984031 6.72E−13
ZNF69 0.117564379 0.142619404 0.278719274 2.66E−08 3.94E−06 − 0.321104504 1.30E−12
FAM84A 0.212175332 0.283041565 0.415757 3.53E−08 5.23E−06 − 0.335916441 9.96E−14
PPP1R14D 0.554947827 0.482097369 − 0.203027589 6.64E−08 9.82E−06 − 0.560710402 7.40E−40
TCP11 0.624104627 0.659912943 0.080487807 7.18E−08 1.06E−05 − 0.651746879 1.43E−57
ZNF300 0.328409005 0.415250076 0.338486746 9.38E−08 1.39E−05 − 0.472110183 3.46E−27
MPV17L 0.092385716 0.163253978 0.821376431 1.86E−07 2.75E−05 − 0.441792534 1.23E−23
KRT20 0.790374237 0.804070021 0.02478522 2.92E−07 4.33E−05 − 0.571800235 1.00E−41
GKN2 0.599299248 0.671212935 0.163493955 4.56E−07 6.76E−05 − 0.340697654 4.22E−14
ZNF502 0.329208879 0.402697069 0.290691725 6.68E−07 9.88E−05 − 0.663271171 2.91E−60
C17orf98 0.545496557 0.602566194 0.143549644 1.03E−06 0.000151843 − 0.529865333 5.12E−35
ZNF880 0.140875018 0.238786926 0.76130805 1.04E−06 0.000154315 − 0.560715099 7.38E−40
ZNF701 0.240700225 0.290476188 0.271182411 1.55E−06 0.000229592 − 0.408643207 3.83E−20
NR0B1 0.283614274 0.392651776 0.469320279 1.59E−06 0.000235507 − 0.320709703 1.39E−12
ZNF43 0.067179039 0.115788942 0.78541442 1.79E−06 0.000265629 − 0.375124186 5.52E−17
HCAR1 0.43400231 0.376162376 − 0.206347167 1.93E−06 0.000285658 − 0.401199574 2.07E−19
IRX2 0.289887257 0.40281496 0.474625351 3.59E−06 0.000530859 − 0.539421825 1.83E−36
TMEM63A 0.188744901 0.177446694 − 0.089051973 4.10E−06 0.000607535 − 0.345096982 1.89E−14
ITPRIPL1 0.294502802 0.374069204 0.345023839 4.14E−06 0.000613146 − 0.44960488 1.61E−24
LYZ 0.699231698 0.733682794 0.069385864 4.77E−06 0.000705417 − 0.424840466 8.40E−22
IFNLR1 0.246226199 0.232227751 − 0.084443891 9.60E−06 0.001421224 − 0.420673159 2.29E−21
TUSC1 0.13659181 0.18296341 0.421684184 9.60E−06 0.001421229 − 0.395587597 7.19E−19
MAGEB2 0.842482835 0.77366049 − 0.122946694 1.08E−05 0.001598591 − 0.352008819 5.20E−15
BVES 0.191406638 0.252664551 0.400582407 1.12E−05 0.001655808 − 0.321449081 1.23E−12
LRRIQ4 0.704379076 0.645150221 − 0.126716926 1.21E−05 0.001791741 − 0.38912631 2.93E−18
RASSF10 0.120420032 0.181039038 0.588225416 5.00E−05 0.007400364 − 0.328252794 3.83E−13
PRICKLE4 0.605330662 0.686379771 0.181283603 8.15E−05 0.012068682 − 0.318883347 1.89E−12
SYCP2 0.665037997 0.675303689 0.022099668 0.000123074 0.018214969 − 0.655943521 1.55E−58
WBP2NL 0.524579367 0.489275744 − 0.1005133 0.000184004 0.027232614 − 0.343246032 2.65E−14
BST2 0.422881206 0.380549863 − 0.152166944 0.000187292 0.027719241 − 0.589617095 7.07E−45
PLSCR4 0.17571366 0.196664014 0.162506649 0.000241916 0.035803514 − 0.365149084 4.10E−16
GBP4 0.149941894 0.137445221 − 0.125546784 0.000249246 0.036888372 − 0.316476516 2.82E−12
RPL7A 0.801995847 0.754500966 − 0.088072019 0.000275207 0.040730644 − 0.319271372 1.77E−12
ARHGDIB 0.327607353 0.313354218 − 0.064173323 0.000282085 0.04174863 − 0.552243 1.77E−38
CYB5A 0.127300153 0.141309476 0.150624055 0.000302943 0.044835593 − 0.371106098 1.25E−16