Skip to main content
Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept

Fig. 4

ECP efficacy relies on the presence of arthritogenic T cells in the treated sample. Mice with established arthritis were left untreated or were injected 3 times with ivPUVA spleen cells taken from arthritic or healthy mice. a Mean and SEM of relative clinical score in 15 mice per group from 3 independent experiments. The three curves represent the calculated nonlinear regression, second order polynomial equations and are statistically different for mice treated with ivPUVA spleen cells from arthritic mice (white circles) compared to untreated mice (black squares) or treated with ivPUVA cells from healthy mice (stars). Bayesian analysis using a Baranyi model also indicated that the A-PUVA curve was different from the two others (Bayes factor > 1000). b Th17 cell percentages were determined, and bars represent the mean for 5 mice per groups in one experiment. Kruskal–Wallis test showed significant differences between the 3 groups (p = 0.016) and Dunns’ post-test was used to compare the 3 groups (*p < 0.05)

Back to article page