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Table 6 Pathways enriched in GSE112047 and GSE76938 datasets

From: Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data

Gene set

Description

Size

Expect

Ratio

p value

FDR

GSE112047

 hsa04728

Dopaminergic synapse

131

2.3422

3.8426

0.0005

0.1734

 hsa05033

Nicotine addiction

40

0.7152

5.5931

0.0054

0.5917

 hsa05031

Amphetamine addiction

68

1.2158

4.1126

0.0072

0.5917

 hsa05146

Amoebiasis

96

1.7164

3.4957

0.0073

0.5917

 hsa04512

ECM-receptor interaction

82

1.4661

3.4104

0.0154

0.8913

 hsa05323

Rheumatoid arthritis

90

1.6091

3.1073

0.0222

0.8913

 hsa00604

Glycosphingolipid biosynthesis

15

0.2682

7.4574

0.0286

0.8913

 hsa04933

AGE-RAGE signaling pathway in diabetic complications

99

1.77

2.8248

0.0318

0.8913

 hsa00380

Tryptophan metabolism

40

0.7152

4.1948

0.0341

0.8913

 hsa00360

Phenylalanine metabolism

17

0.3039

6.5801

0.0362

0.8913

GSE76938

 hsa05033

Nicotine addiction

40

1.1993

9.1721

1.47E−08

4.8E−06

 hsa05032

Morphine addiction

91

2.7284

4.7647

2.68E−06

0.0004

 hsa04723

Retrograde endocannabinoid signaling

148

4.4374

3.3804

0

0.0029

 hsa04933

AGE-RAGE signaling pathway in diabetic complications

99

2.9682

4.0428

0

0.0029

 hsa04080

Neuroactive ligand-receptor interaction

277

8.305

2.5286

0.0001

0.0051

 hsa05146

Amoebiasis

96

2.8783

3.8217

0.0001

0.007

 hsa04727

GABAergic synapse

88

2.6384

3.7901

0.0003

0.013

 hsa04728

Dopaminergic synapse

131

3.9277

3.0553

0.0005

0.0191

 hsa05144

Malaria

49

1.4691

4.7647

0.0006

0.0191

 hsa04724

Glutamatergic synapse

114

3.418

3.2183

0.0006

0.0191