Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data

Table 5 GO terms enriched in GSE112047 and GSE76938 datasets

Gene set	Description	Size	Expect	Ratio	p value	FDR
GSE112047
GO:0045595	Regulation of cell differentiation	1699	28.866	2.1479	5.48E−09	0.0001
GO:0031012	Extracellular matrix	496	8.4271	3.3226	3.00E−08	0.0002
GO:0007155	Cell adhesion	1369	23.259	2.1067	5.21E−07	0.0016
GO:0061061	Muscle structure development	610	10.364	2.7982	6.40E−07	0.0016
GO:0030182	Neuron differentiation	1313	22.308	2.1069	9.19E−07	0.0016
GO:0005540	Hyaluronic acid binding	22	0.3738	16.052	1.3596E−06	0.0021
GO:2000026	Regulation of multicellular organismal development	1908	32.417	1.82	3.8179E−06	0.0046
GSE76938
GO:0043062	Extracellular structure organization	400	11.623	2.8392	7.43E−08	0
GO:0031012	Extracellular matrix	496	14.412	3.1223	1.20E−11	1.56E−08
GO:0021953	Central nervous system neuron differentiation	179	5.2012	4.2298	1.19E−08	7.73E−06
GO:0001505	Regulation of neurotransmitter levels	335	9.7341	2.9792	1.70E−07	0.0001
GO:0045165	Cell fate commitment	249	7.2352	3.3171	2.86E−07	0.0001
GO:1990351	Transporter complex	332	9.6469	2.9025	4.73E−07	0.0001
GO:0050769	Positive regulation of neurogenesis	447	12.989	2.5407	9.50E−07	0.0002
GO:0043025	Neuronal cell body	486	14.122	2.4076	2.17E−06	0.0004
GO:0005201	Extracellular matrix structural constituent	158	4.591	3.7029	3.55E−06	0.0005
GO:0042391	Regulation of membrane potential	414	12.03	2.4938	4.34E−06	0.0005

ISSN: 1479-5876