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Table 2 Top 10 hypomethylated genes and hypermethylated genes in patients with prostate cancer

From: Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data

Gene

Normal mean

Tumor mean

Log FC

p value

Adjust p

Cor

Cor p value

Top 10 hypomethylated genes

 TAF1D

0.298851771

0.17046481

− 0.809956148

5.12E−22

1.61E−19

− 0.515133904

3.62E−35

 TMEM87A

0.36898334

0.219989007

− 0.746124244

2.40E−22

7.57E−20

− 0.415783216

2.80E−22

 KLK2

0.42230197

0.252663444

− 0.741058027

2.34E−25

7.36E−23

− 0.424469057

3.03E−23

 MARS

0.661117252

0.407190703

− 0.69920154

2.88E−18

9.08E−16

− 0.402813221

6.87E−21

 SLC10A5

0.682378547

0.421046571

-0.696592477

1.19E−16

3.76E−14

− 0.320114016

2.36E−13

 KLK3

0.528659515

0.348234132

− 0.602281232

2.38E−22

7.50E−20

− 0.352378214

4.92E−16

 MPC2

0.847716806

0.573604393

− 0.563526315

3.24E−22

1.02E−19

− 0.509873152

2.25E−34

 ALDH1A3

0.390659331

0.266302408

− 0.552845598

6.96E−20

2.19E−17

− 0.500862763

4.78E−33

 CLDN8

0.556942422

0.387056997

− 0.524982157

1.24E−14

3.91E−12

− 0.339347771

6.50E−15

 PMEPA1

0.427234317

0.301507194

− 0.50283511

1.93E−21

6.07E−19

− 0.559861766

1.65E−42

Top 10 hypermethylated genes

 HIST1H2BH

0.073047

0.264894

1.858512

1.40E−15

4.41E−13

− 0.37138

9.15E−18

 FAM200A

0.052277

0.163374

1.643934

1.78E−18

5.60E−16

− 0.32491

9.86E−14

 ZFP36L2

0.101664

0.293078

1.527482

1.59E−13

5.02E−11

− 0.47382

2.72E−29

 WFDC2

0.125846

0.347072

1.463575

2.89E−24

9.09E−22

− 0.46874

1.27E−28

 SMIM10

0.169555

0.460955

1.44287

1.29E−18

4.06E−16

− 0.52098

4.58E−36

 RIPPLY2

0.06161

0.166659

1.435669

4.35E−23

1.37E−20

− 0.33215

2.57E−14

 RTP4

0.102519

0.273692

1.416666

4.91E−19

1.55E−16

− 0.51074

1.67E−34

 FBXO27

0.048294

0.126663

1.391093

3.13E−12

9.85E−10

− 0.64419

7.67E−60

 ZNF492

0.057359

0.147069

1.358401

3.63E−20

1.14E−17

− 0.33472

1.58E−14

 HPDL

0.14249

0.356177

1.321732

5.48E−20

1.73E−17

− 0.54417

8.31E−40

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Journal of Translational Medicine

ISSN: 1479-5876

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