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Table 4 Collagen-targeted agents directly influencing collagen content and distribution in clinical trials for cancers

From: The role of collagen in cancer: from bench to bedside

Drug Combination drugs Cancer Phase Status Result Reference number
LDE225 Gemcitabine, Nab-paclitaxel Locally Advanced or Metastasized Pancreatic Cancer I/II Unknown   NCT02358161
EN3835 None Uterine Leiomyoma I Completed Enough safety and efficacy, and decreased tumor bulk NCT02889848
EN3835 None Lipoma II Completed dose escalation study NCT01613313
Losartan Proton beam radiation, FOLFIRINOX Locally Advanced Pancreatic Cancer II Active, not recruiting   NCT01821729
TRC093 None Locally Advanced or Metastatic Solid Tumors I Completed Dose escalation study NCT00492830
Halofuginone hydrobromide None Human immunodeficiency virus-related Kaposi’s sarcoma II Completed No clear clinical benefits NCT00064142