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Table 3 Typical inhibitors and drugs that regulate collagen biosynthesized processes and collagen distribution arrangement in cancer studies

From: The role of collagen in cancer: from bench to bedside

Effects of inhibitors Targeted sites of inhibitors Typical inhibitors and drugs References
Interfering collagen biosynthesis enzymes Collagen genes MiR-129-5p, MiR-29b, MiR-384 [275,276,277]
Prolyl 4-hydroxylase Budesonide, catechol, N-oxalylglycine, coumalic acid, ethyl dihydroxybenzoic acid [278,279,280]
Heat shock protein 90 1G6-D7, dipalmitoyl-radicicol, 17-DMAG, ganetespib [281,282,283,284]
Heat shock protein 47 MiR-29, 1,3-dimethylol-5-FU, AK778, pirfenidone, terutroban [285, 286]
Matrix metalloproteinases Gallium complex GS2, isoflavonoids, bisphosphonates [287, 288]
Lysyl oxidases Beta-aminopropionitrile [289]
Disturbing cancer cell signaling pathways Snail transcription factors Toosendanin, ponicidin, ferulic acid [290]
Hypoxia‐inducible factor Tamoxifen, 28-O-propynoylbetulin [291, 292]
STAT3 signaling pathway VS-4718, stattic, ruxolitinib, S3I-201 [293, 294]
TGF‐β signaling pathway LY2157299 monohydrate, trabedersen, fresolimumab, galunisertib [295, 296]
NF‐κB signaling pathway Honokiol, aspirin, ormeloxifene [297,298,299]
AKT signaling pathway Quetiapine, pirfenidone [300]
Notch signaling pathway Rovalpituzumab tesirine, taladegib, crenigacestat, MiR-148a [301]
Hedgehog signaling pathway Itraconazole, sonidegib, vismodegib [302]
RAS signaling pathway Perindopril, losartan [100, 303]
Tyrosine kinase receptor Bevacizumab, imatinib, ponatinib, dasatinib [304, 305]
Discoidin domain receptor WRG-28, 7rh, AZD0156 [306,307,308]
G protein family receptor AT13148, KD025, Azaindole 1, chelerythrine [309]
Integrin Cilengitide, volociximab, intetumumab, LM609 [310]
Mediating tumor matrix components Macrophage Bone-marrow-derived macrophages infusion [141]
T cell Tumor-targeted trimeric 4-1BB-agonistic antibody [311]
Cancer-associated fibroblasts ABT-199, 5-AZA, ismodegib, metformin, Nab-paclitaxel [312, 313]
Hyaluronic acid Halofuginone [314]
Directly utilizing collagenase Collagen antibody Collagen-binding EGFR single-chain Fv antibody fragment [224]
Nanoparticle Poly-lactic-co-glycolic acid nanoparticle, Lipid-bilayer mesoporous silica nanoformulations [222, 315]
Oncolytic adenovirus oH(E)mT-DCN, LOAd703 [316, 317]