Table 3 Typical inhibitors and drugs that regulate collagen biosynthesized processes and collagen distribution arrangement in cancer studies

Interfering collagen biosynthesis enzymes

Collagen genes

MiR-129-5p, MiR-29b, MiR-384

[275,276,277]

Prolyl 4-hydroxylase

Budesonide, catechol, N-oxalylglycine, coumalic acid, ethyl dihydroxybenzoic acid

[278,279,280]

Heat shock protein 90

1G6-D7, dipalmitoyl-radicicol, 17-DMAG, ganetespib

[281,282,283,284]

Heat shock protein 47

MiR-29, 1,3-dimethylol-5-FU, AK778, pirfenidone, terutroban

[285, 286]

Matrix metalloproteinases

Gallium complex GS2, isoflavonoids, bisphosphonates

[287, 288]

Lysyl oxidases

Beta-aminopropionitrile

[289]

Disturbing cancer cell signaling pathways

Snail transcription factors

Toosendanin, ponicidin, ferulic acid

[290]

Hypoxia‐inducible factor

Tamoxifen, 28-O-propynoylbetulin

[291, 292]

STAT3 signaling pathway

VS-4718, stattic, ruxolitinib, S3I-201

[293, 294]

TGF‐β signaling pathway

LY2157299 monohydrate, trabedersen, fresolimumab, galunisertib

[295, 296]

NF‐κB signaling pathway

Honokiol, aspirin, ormeloxifene

[297,298,299]

AKT signaling pathway

Quetiapine, pirfenidone

[300]

Notch signaling pathway

Rovalpituzumab tesirine, taladegib, crenigacestat, MiR-148a

[301]

Hedgehog signaling pathway

Itraconazole, sonidegib, vismodegib

[302]

RAS signaling pathway

Perindopril, losartan

[100, 303]

Tyrosine kinase receptor

Bevacizumab, imatinib, ponatinib, dasatinib

[304, 305]

Discoidin domain receptor

WRG-28, 7rh, AZD0156

[306,307,308]

G protein family receptor

AT13148, KD025, Azaindole 1, chelerythrine

[309]

Integrin

Cilengitide, volociximab, intetumumab, LM609

[310]

Mediating tumor matrix components

Macrophage

Bone-marrow-derived macrophages infusion

[141]

T cell

Tumor-targeted trimeric 4-1BB-agonistic antibody

[311]

Cancer-associated fibroblasts

ABT-199, 5-AZA, ismodegib, metformin, Nab-paclitaxel

[312, 313]

Hyaluronic acid

Halofuginone

[314]

Directly utilizing collagenase

Collagen antibody

Collagen-binding EGFR single-chain Fv antibody fragment

[224]

Nanoparticle

Poly-lactic-co-glycolic acid nanoparticle, Lipid-bilayer mesoporous silica nanoformulations

[222, 315]

Oncolytic adenovirus

oH(E)mT-DCN, LOAd703

[316, 317]