Fig. 2

Biomarker panel for prediction of prostate cancer aggressiveness. Box plot representing significant changes of biomarker levels in different biofluids: a Serum total PSA, b sTWEAK semen levels, c mRNA levels in semen cell sediment of: Fn14, KLK2, CXCR2 and CCR3, and d fasting glucose levels. Values of each biomarker are expressed as mean ± SD. Differences between patients according to Gleason stage coded into two categories: low-risk ISUP GG (group I and II) or high-risk ISUP GG (group III, IV and V) were tested with the Mann–Whitney U test for non-normally distributed data. p-values less than 0.05 were considered statistically significant