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Table 2 Multivariable analysis

From: Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy

Variable PFS as the dependent variable OS as the dependent variable
Univariate Multivariable Univariate Multivariable
HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value HR (95% CI) p-value
Baseline LDH 2.79 (1.55–5.03) < 0.001    3.37 (1.65–6.89) < 0.001   
Baseline CRP 2.38 (1.28–4.42) 0.006 2.16 (1.15–4.07) 0.017 2.43 (1.17–5.06) 0.017   
ECOG 2.87 (1.20–6.90) 0.018 2.67 (1.04–6.84) 0.04 4.02 (1.65–9.79) 0.002   
Number of metastatic sites 2.33 (1.28–4.26) 0.006    3.06 (1.44–6.52) 0.004 2.38 (1.10–5.14) 0.027
Undetectable ctDNA 0.18 (0.09–0.35) < 0.001 0.20 (0.10–0.40) < 0.001 0.13 (0.06–0.29) < 0.001 0.16 (0.07–0.36) < 0.001
  1. Univariate and multivariable regression analyses were performed using cox regression model. Factors associated with the occurrence of OS and PFS (ctDNA, LDH, CRP, number of tumor sites and ECOG variables) were considered in the analyses. The results are presented as hazard ratios with 95% confidence intervals and p values