Fig. 5

TREM2 deficiency up-regulated macrophage pro-inflammatory cytokine expressions of macrophages in mice of HFD. WT and TREM2^−/− mice of C57BL/6 of 6 weeks were fed with HFD for 12 weeks. Inflammatory cytokines were measured with RT-PCR. Relative expression levels of a TNF-α, b IL-1β, c IL-6 and d iNOS of macrophages of epididymal adipose tissue of WT and TREM2^−/− mice after 12 weeks of HFD feeding (N = 8/group). Data are presented as means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001