Table 5 Axitinib toxicity
Adverse event (%) | Standard dose | Titration | ||||
|---|---|---|---|---|---|---|
Grade 1–2 87.3% | Grade 3 12.7% | Grade 4 0% | Grade 1–2 86.6% | Grade 3 13.4% | Grade 4 0% | |
Haematologic | 9.5 | 0.7 | – | 11.4 | 2 | – |
Hypertension | 20.9 | 5.4 | – | 25.7 | 5.7 | – |
Gastro-intestinal | 32.4 | 4.1 | – | 34.3 | – | – |
Hypothyroidism | 17.6 | 0.7 | – | 25.7 | – | – |
Stomatitis/mucositis | 8.1 | – | – | 8.5 | – | – |
Fatigue | 43.2 | 7.4 | – | 48.6 | 8.6 | – |
Hepatic | 2.8 | 2 | – | 2.9 | 5.7 | – |
Hand-foot syndrome | 12.2 | 2 | – | 17.2 | 2.9 | – |
Dysphonia | 11.5 | 0.7 | – | 11.4 | 2.9 | – |