Table 1 Body weight and fasting plasma levels of lipids, glucose and insulin of LDLr−/− mice treated with pravastatin for 3, 6 and 10 months
| Â | 3Â months | 6Â months | 10Â months | |||
|---|---|---|---|---|---|---|
Control | Pravastatin | Control | Pravastatin | Control | Pravastatina | |
Body weight (g) | 19.6 ± 0.4 (6) | 19.17 ± 0.3 (6) | 22.47 ± 0.2 (6) | 22.05 ± 0.7 (6) | 23.00 ± 0.3 (5) | 21.55 ± 0.4 (4)* |
Cholesterol (mg/dL) | 584.6 ± 37.5 (6) | 324.8 ± 28.6 (6)* | 506.5 ± 22.8 (6) | 272.0 ± 15.8 (6)* | 514.7 ± 32.1 8 (5) | 361.1 ± 46.7 (4)* |
Triglycerides (mg/dL) | 209.3 ± 44.7 (5) | 148.4 ± 23.5 (5) | 145.0 ± 17.1 (6) | 124.9 ± 19.4 (6) | 188.4 ± 22.2 (5) | 108.1 ± 13.0 (4)* |
Glucose (mg/dL) | 89.20 ± 4.7 (6) | 77.46 ± 3.4 (6) | 96.3 ± 3.0 (6) | 90.7 ± 4.4 (6) | 92.4 ± 3.4 (5) | 102.0 ± 6.6 (4) |
Insulin (ng/mL) | 0.44 ± 0.16 (4) | 0.49 ± 0.10(4) | 0.42 ± 0.03 (6) | 0.45 ± 0.04 (6) | 0.39 ± 0.06 (5) | 0.33 ± 0.04 (4) |
Glucose/insulin | 188 ± 41 (4) | 172 ± 38 (4) | 267 ± 46 (6) | 224 ± 27 (6) | 258 ± 25 (5) | 337 ± 49 (4) |