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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic mice

Fig. 4

Long-term pravastatin treatment increases protein degradation in the gastrocnemius muscle of LDLr−/− mice. a Rate of protein degradation in the gastrocnemius muscle of LDLr−/− mice treated with pravastatin for 10 months, measured by the tyrosine released into the incubation medium. b Rate of protein synthesis in the gastrocnemius muscle of LDLr−/− mice, measured by the 3H-phenylalanine incorporated into muscle proteins. c Total muscle protein concentrations in the gastrocnemius. Mean ± SE. *p < 0.05 as determined by Student’s t-test between untreated (control) and pravastatin-treated mice (n = 4–5)

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