Fig. 3

Long-term pravastatin treatment reduces ex vivo insulin secretion. Insulin secretion from isolated islets of LDLr^−/− mice in the presence of 2.8 or 11.1 mM glucose after 3 months (a), 6 months (b) and 10 months (c) of pravastatin treatment. Mean ± SE. *p < 0.05 as determined by Student’s t-test between untreated (control) and pravastatin-treated mice (n = 4–6 mice)