Fig. 1

Long-term pravastatin treatment causes glucose intolerance in LDLr^−/− mice. A glucose tolerance test (GTT) was performed after 3 months (a, b), 6 months (c, d) and 10 months (e, f) of treatment. Blood glucose concentrations (a, c and d) and area under the curve (AUC) are represented (b, d and f). Mean ± SE. *p < 0.05 as determined by Student’s t-test between untreated and pravastatin-treated mice (n = 4–6)