Fig. 1

Irradiation (IR) modulates keratin expression patterns and suppresses wound-healing capacity of keratinocytes in mouse skin (40 Gy delivered locally). a Differing K10/K14 positivity on immunostain in normal and irradiated mouse skin. b Western blot analysis of K10 and K14 expression levels in normal and irradiated mouse skin, day 7, 28. Results of one experiment performed in triplicate and expressed as mean ± SEM *p < 0.05 vs. CTL group. c Expression levels of keratins 1, 10, and 14 in HaCaT cells irradiated at different doses, incubated for 24 h; and d wound-healing capacity of HaCaT cells irradiated at different doses, using scratch-simulated wound migration assay. Results of one experiment performed in triplicate and expressed as mean ± SEM (Student’s t test applied) *p < 0.05 vs. 0-Gy group. CTL control