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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Aryl hydrocarbon receptor ligands enhance lung immunity through intestinal IKKβ pathways

Fig. 1

Oral supplementation with Trp, or dead L. plantaris decreases P. aeruginosa pneumonia-induced bacterial counts and ICAM and IL-6 expression of the lung under antibiotic treatment. C57BL/6 male mice received a combined intramuscular injection of antibiotics: ampicillin, vancomycin, and metronidazole for 6 days. Tryptophan, indole, or dead L. plantaris were given to mouse. a Intramuscular combined antibiotics with or without Trp or dL.P. supplementation were given to mice for 6 days. The trachea of mice was surgically exposed and 50 μl (1.0 × 107 CFU P. aeruginosa) were instilled via an angiocatheter through the trachea to induce P. aeruginosa pneumonia. Data are presented as mean ± SEM. b Antibiotic treatment significantly increased ICAM and mRNA expression in the lung and Trp, or dead L. plantaris feeding decreased it. Data are presented as mean ± SEM. c Antibiotic treatment increased IL-6 mRNA expression in the lung and Trp, or dead L. plantaris feeding decreased it. Data are presented as mean ± SEM; PA, P. aeruginosa; *P < 0.05, **P < 0.01

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