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Table 4 Consistency in BRAF and NRAS pathogenic/likely pathogenic variants in our cohort

From: Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach

  Cases with a mutation in the primary tumor Consistent mutation pattern with metastasis (%)
BRAF mutations
 Primary vs. lymph node metastasis 18 17 (94.4)
 Primary vs. visceral metastasis 3 3 (100)
 Primary vs. metastasis 21 20 (95.2)
 Discovery cohort 17 17 (100)
 Validation cohort 4 3 (75)
NRAS mutations
 Primary vs. lymph node metastasis 3 3 (100)
 Primary vs. visceral metastasis 4 3 (75)
 Primary vs. metastasis 7 6 (85.7)
 Discovery cohort 5 4 (80)
 Validation cohort 2 2 (100)