Table 2 Consistency between pathogenic/likely pathogenic mutation patterns in paired primary and metastatic lesions: A—all cases, B—discovery cohort, C—validation cohort
Paired tissue types | No. of samples | Cases with consistent mutation pattern (%) | Cases with discrepant mutation pattern (%) |
|---|---|---|---|
A. All cases | |||
 Primary vs. lymph node metastasis | 31 | 27 (87) | 4 (13) |
 Primary vs. visceral metastasis | 18 | 10 (56) | 8 (44) |
 Primary vs. metastasis | 49 | 37 (76) | 12 (24) |
B. Discovery cohort | |||
 Primary vs. lymph node metastasis | 23 | 20 (87) | 3 (13) |
 Primary vs. visceral metastasis | 15 | 8 (53) | 7 (47) |
 Primary vs. metastasis | 38 | 28 (74) | 10 (26) |
C. Validation cohort | |||
 Primary vs. lymph node metastasis | 8 | 7 (87.5) | 1 (12.5) |
 Primary vs. visceral metastasis | 3 | 2 (67) | 1 (33) |
 Primary vs. metastasis | 11 | 9 (82) | 2 (18) |