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Table 2 Consistency between pathogenic/likely pathogenic mutation patterns in paired primary and metastatic lesions: A—all cases, B—discovery cohort, C—validation cohort

From: Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach

Paired tissue types No. of samples Cases with consistent mutation pattern (%) Cases with discrepant mutation pattern (%)
A. All cases
 Primary vs. lymph node metastasis 31 27 (87) 4 (13)
 Primary vs. visceral metastasis 18 10 (56) 8 (44)
 Primary vs. metastasis 49 37 (76) 12 (24)
B. Discovery cohort
 Primary vs. lymph node metastasis 23 20 (87) 3 (13)
 Primary vs. visceral metastasis 15 8 (53) 7 (47)
 Primary vs. metastasis 38 28 (74) 10 (26)
C. Validation cohort
 Primary vs. lymph node metastasis 8 7 (87.5) 1 (12.5)
 Primary vs. visceral metastasis 3 2 (67) 1 (33)
 Primary vs. metastasis 11 9 (82) 2 (18)