From: Cryopreserved mesenchymal stem cells regain functional potency following a 24-h acclimation period
HMGB1 | High mobility group box 1; DNA binding protein involved in tissue damage |
TRL4 | Toll-like receptor 4; play role in activation of innate immunity |
TNF-α | Tumor necrosis factor alpha; upregulated in inflammation |
CYCS | Cytochrome c; involved in initiation of apoptosis |
BCL2 | B-cell lymphoma 2; regulates apoptosis |
BAX | BCL-2-like protein 4; apoptosis activator |
CASP3 | Caspase 3; apoptosis activator |
NANOG | Transcription factor essential for pluripotency |
SOX2 | Sex determining region Y-box 2; transcription factor essential for pluripotency |
OCT-4 | Octamer-binding transcription factor 4; transcription factor essential for pluripotency |
TNFAIP6 | Tumor necrosis factor-inducible gene 6 protein; involved in macrophage polarization (M1 to M2 phenotype) |
VEGF | Vascular endothelial growth factor; essential for angiogenesis |
HMOX-1 | Heme oxygenase 1; anti-inflammatory upregulates IL-10 and IL-1ra |
STC-1 | Stanniocalcin 1; regulation of metabolism and calcium/phosphate homeostasis |
CAT | Catalase; catalyzes hydrogen peroxide to protect cell from reactive oxygen species |
VCAM1 | Vascular cell adhesion molecule 1; mediates adhesion of various immune cells |
ICAM1 | Intercellular adhesion molecule 1; mediates adhesion of leukocytes when activated |