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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Cryopreserved mesenchymal stem cells regain functional potency following a 24-h acclimation period

Fig. 4Fig. 4

Immunosuppressive and anti-inflammatory properties of MSCs from the 3 groups in a co-culture system. a All groups were able to suppress T-cell proliferation, but the TT group performed significantly better, whereas the FT cells were the least potent. b All MSCs were able to suppress the secretion of the pro-inflammatory cytokines IFN-γ, TNF-α, and IL-13. c Following a LPS challenge, all MSCs were able to suppress the secretion of the pro-inflammatory cytokines IL-β and TNF-α with concomitant increase in the secretion of the anti-inflammatories IL-1RA and IL-10. Additionally, the FC cells secreted significantly more IFN-γ than all other groups. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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