TY - JOUR AU - Bartholomeus, Esther AU - De Neuter, Nicolas AU - Lemay, Annelies AU - Pattyn, Luc AU - Tuerlinckx, David AU - Weynants, David AU - Van Lede, Koen AU - van Berlaer, Gerlant AU - Bulckaert, Dominique AU - Boiy, Tine AU - Vander Auwera, Ann AU - Raes, Marc AU - Van der Linden, Dimitri AU - Verhelst, Helene AU - Van Steijn, Susanne AU - Jonckheer, Tijl AU - Dehoorne, Joke AU - Joos, Rik AU - Jansens, Hilde AU - Suls, Arvid AU - Van Damme, Pierre AU - Laukens, Kris AU - Mortier, Geert AU - Meysman, Pieter AU - Ogunjimi, Benson PY - 2019 DA - 2019/08/23 TI - Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture? JO - Journal of Translational Medicine SP - 282 VL - 17 IS - 1 AB - Meningitis can be caused by several viruses and bacteria. Identifying the causative pathogen as quickly as possible is crucial to initiate the most optimal therapy, as acute bacterial meningitis is associated with a significant morbidity and mortality. Bacterial meningitis requires antibiotics, as opposed to enteroviral meningitis, which only requires supportive therapy. Clinical presentation is usually not sufficient to differentiate between viral and bacterial meningitis, thereby necessitating cerebrospinal fluid (CSF) analysis by PCR and/or time-consuming bacterial cultures. However, collecting CSF in children is not always feasible and a rather invasive procedure. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-019-2037-6 DO - 10.1186/s12967-019-2037-6 ID - Bartholomeus2019 ER -