Fig. 2

Concurrent oncogenic mutations based on BRAF mutation class. a Mutation spectrum in the 8 classic NSCLC oncogenic driver of the 238 BRAF-mutant patients. The patients were grouped according to BRAF mutation class as indicated by the bar located at the bottom of the oncoprint. Each column represents a patient and each row represents a gene. Table on the left represents the mutation rate of each gene. Top plot represents the overall number of mutations a patient carried. Different colors denote different types of mutation. b Concurrent KRAS mutations in different BRAF mutation classes. Class I BRAF mutations were mutually exclusive from KRAS, while class 2 (P = 0.025) and 3 (P < 0.01) were more likely to have concurrent KRAS mutations. X-axis denotes the BRAF mutant class. Y-axis denotes the number of mutations in either BRAF or KRAS