Table 2 A list of model variables
From: Transitioning from acute to chronic pain: a simulation study of trajectories of low back pain
The cortisol dynamics can be simulated in the HPA model by solving the coupled differential equations as proposed in Sriram et al. [47], where the variables and parameters are listed as follows: | |
CRH | Corticotrophin-releasing hormone |
ACTH | Adreno-corticotrophin hormone |
CORT | Cortisol |
GR | Glucocorticoid receptor complex |
Gtot | Total glucocorticoid receptor |
Kstress | Stress or pain induced parameter |
Ki | Inhibition constant that regulates the strength of the negative feedback loop |
Vs3, Vs4, Vs5 | Rates at which the hormones CRH, ACTH and CORT are degraded enzymatically through saturation kinetics |
Km1, Km2, Km3 | Michaelis constant |
Kd1, Kd2, Kd3, Kd5 | Autonomous degradation constants |
Kp2, Kp3, Kb | Rates of production of ACTH,CORT and GR |
n1, n2 | Hill constants |
K1 | Activation constant |