Fig. 1From: Transitioning from acute to chronic pain: a simulation study of trajectories of low back painA Diagram of Hypothalamic–Pituitary–Adrenal (HPA) axis. In response to stress, the hypothalamus releases CRH, which activates the pituitary which secretes ACTH. ACTH stimulates the adrenal to secrete glucocorticoid. Glucocorticoid performs a negative feedback on the secretion of CRH and ACTHBack to article page