Fig. 12

Kaplan–Meier (K–M) survival plots and receiver operating characteristic (ROC) curves of factors predictive of undifferentiated pleomorphic sarcoma. a–f K–M curves and ROC curves with AUCs of prognostic factors based on one type of alternative splicing event in undifferentiated pleomorphic sarcoma patients (a AD; b AP; c AT; d ES; e ME; f RI). An AA event was not available and, thus, could not be included in the analysis. g A K–M curve and ROC curve with AUC of the final prognostic factors based on merged types of alternative splicing events in undifferentiated pleomorphic sarcoma. Prognostic models were constructed with the alternative splicing events that proved to be independent factors in the multivariate Cox regression analysis. AA alternate acceptors, AD alternate donors, AP alternate promoters, AT alternate terminators, ES exon skips, ME mutually exclusive exon, RI retained intron, AUC area under the curve, K–M Kaplan–Meier, ROC receiver operating characteristic