From: Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors
Parameters | Total n = 338 (%) | Histologic subtype | p-value | BRAF V600E mutation status | p-value | ||
---|---|---|---|---|---|---|---|
Follicular variant n = 36 (%) | Conventional type n = 302 (%) | No mutation n = 102 (%) | Mutation n = 238 (%) | ||||
ATX | 0.002 | < 0.001 | |||||
Negative | 220 (65.1) | 32 (88.9) | 188 (62.3) | 91 (89.2) | 129 (54.7) | ||
Positive | 118 (34.8) | 4 (11.1) | 114 (37.7) | 11 (10.8) | 107 (45.3) | ||
LPA1 | 0.014 | < 0.001 | |||||
Negative | 169 (50.0) | 25 (69.4) | 144 (47.7) | 88 (86.3) | 81 (34.3) | ||
Positive | 169 (50.0) | 11 (30.6) | 158 (52.3) | 14 (13.7) | 155 (65.7) | ||
LPA1 (S) | 0.609 | 0.380 | |||||
Negative | 323 (95.6) | 35 (97.2) | 288 (95.4) | 99 (97.1) | 224 (94.9) | ||
Positive | 15 (4.4) | 1 (2.8) | 14 (4.6) | 3 (2.9) | 12 (5.1) | ||
LPA2 | 0.001 | < 0.001 | |||||
Negative | 191 (56.5) | 30 (83.3) | 161 (53.3) | 86 (84.3) | 105 (44.5) | ||
Positive | 147 (43.5) | 6 (16.7) | 141 (46.7) | 16 (15.7) | 131 (55.5) | ||
LPA3 | 0.150 | < 0.001 | |||||
Negative | 56 (16.6) | 9 (25.0) | 47 (15.6) | 42 (41.2) | 14 (5.9) | ||
Positive | 282 (83.4) | 27 (75.0) | 255 (84.4) | 60 (58.8) | 222 (94.1) |