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Table 2 Expression of proteins related to the ATX–LPA axis according to the histologic subtype of PTC

From: Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

Parameters

Total

n = 338 (%)

Histologic subtype

p-value

BRAF V600E mutation status

p-value

Follicular variant

n = 36 (%)

Conventional type

n = 302 (%)

No mutation

n = 102 (%)

Mutation

n = 238 (%)

ATX

0.002

  

<0.001

 Negative

220 (65.1)

32 (88.9)

188 (62.3)

 

91 (89.2)

129 (54.7)

 

 Positive

118 (34.8)

4 (11.1)

114 (37.7)

 

11 (10.8)

107 (45.3)

 

LPA1

0.014

  

<0.001

 Negative

169 (50.0)

25 (69.4)

144 (47.7)

 

88 (86.3)

81 (34.3)

 

 Positive

169 (50.0)

11 (30.6)

158 (52.3)

 

14 (13.7)

155 (65.7)

 

LPA1 (S)

0.609

  

0.380

 Negative

323 (95.6)

35 (97.2)

288 (95.4)

 

99 (97.1)

224 (94.9)

 

 Positive

15 (4.4)

1 (2.8)

14 (4.6)

 

3 (2.9)

12 (5.1)

 

LPA2

0.001

  

<0.001

 Negative

191 (56.5)

30 (83.3)

161 (53.3)

 

86 (84.3)

105 (44.5)

 

 Positive

147 (43.5)

6 (16.7)

141 (46.7)

 

16 (15.7)

131 (55.5)

 

LPA3

0.150

  

<0.001

 Negative

56 (16.6)

9 (25.0)

47 (15.6)

 

42 (41.2)

14 (5.9)

 

 Positive

282 (83.4)

27 (75.0)

255 (84.4)

 

60 (58.8)

222 (94.1)

 
  1. Italic values represent significance of p-value (p < 0.05)