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Table 2 Expression of proteins related to the ATX–LPA axis according to the histologic subtype of PTC

From: Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

Parameters Total
n = 338 (%)
Histologic subtype p-value BRAF V600E mutation status p-value
Follicular variant
n = 36 (%)
Conventional type
n = 302 (%)
No mutation
n = 102 (%)
Mutation
n = 238 (%)
ATX 0.002    <0.001
 Negative 220 (65.1) 32 (88.9) 188 (62.3)   91 (89.2) 129 (54.7)  
 Positive 118 (34.8) 4 (11.1) 114 (37.7)   11 (10.8) 107 (45.3)  
LPA1 0.014    <0.001
 Negative 169 (50.0) 25 (69.4) 144 (47.7)   88 (86.3) 81 (34.3)  
 Positive 169 (50.0) 11 (30.6) 158 (52.3)   14 (13.7) 155 (65.7)  
LPA1 (S) 0.609    0.380
 Negative 323 (95.6) 35 (97.2) 288 (95.4)   99 (97.1) 224 (94.9)  
 Positive 15 (4.4) 1 (2.8) 14 (4.6)   3 (2.9) 12 (5.1)  
LPA2 0.001    <0.001
 Negative 191 (56.5) 30 (83.3) 161 (53.3)   86 (84.3) 105 (44.5)  
 Positive 147 (43.5) 6 (16.7) 141 (46.7)   16 (15.7) 131 (55.5)  
LPA3 0.150    <0.001
 Negative 56 (16.6) 9 (25.0) 47 (15.6)   42 (41.2) 14 (5.9)  
 Positive 282 (83.4) 27 (75.0) 255 (84.4)   60 (58.8) 222 (94.1)  
  1. Italic values represent significance of p-value (p < 0.05)