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Table 1 Expression of ATX–LPA axis-related proteins according to the histologic subtype of thyroid cancer

From: Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

Parameters Total
n = 545 (%)
PTC
n = 338 (%)
FC
n = 111 (%)
MC
n = 69 (%)
PDC
n = 23 (%)
AC
n = 4 (%)
p-value
ATX <0.001
 Negative 368 (67.5) 220 (65.1) 102 (91.9) 22 (31.9) 21 (91.3) 3 (75.0)  
 Positive 177 (32.5) 118 (34.9) 9 (8.1) 47 (68.1) 2 (8.7) 1 (25.0)  
LPA1 <0.001
 Negative 292 (53.6) 169 (50.0) 73 (65.8) 44 (63.8) 5 (21.7) 1 (25.0)  
 Positive 253 (46.4) 169 (50.0) 38 (34.2) 25 (36.2) 18 (78.3) 3 (75.0)  
LPA1 (S) 0.051
 Negative 530 (97.2) 323 (95.6) 111 (100.0) 69 (100.0) 23 (100.0) 4 (100.0)  
 Positive 15 (2.8) 15 (4.4) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0)  
LPA2 <0.001
 Negative 365 (67.0) 191 (56.5) 85 (76.6) 69 (100.0) 16 (69.6) 4 (100.0)  
 Positive 180 (33.0) 147 (43.5) 26 (23.4) 0 (0.0) 7 (30.4) 0 (0.0)  
LPA3 <0.001
 Negative 189 (34.7) 56 (16.6) 52 (46.8) 67 (97.1) 10 (43.5) 4 (100.0)  
 Positive 356 (65.3) 282 (83.4) 59 (53.2) 2 (2.9) 13 (56.5) 0 (0.0)  
  1. Italic values represent significance of p-value (p < 0.05)
  2. PTC papillary thyroid carcinoma, FC follicular carcinoma, MC medullary carcinoma, PDC poorly differentiated carcinoma, AC anaplastic carcinoma