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Table 1 Expression of ATX–LPA axis-related proteins according to the histologic subtype of thyroid cancer

From: Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

Parameters

Total

n = 545 (%)

PTC

n = 338 (%)

FC

n = 111 (%)

MC

n = 69 (%)

PDC

n = 23 (%)

AC

n = 4 (%)

p-value

ATX

<0.001

 Negative

368 (67.5)

220 (65.1)

102 (91.9)

22 (31.9)

21 (91.3)

3 (75.0)

 

 Positive

177 (32.5)

118 (34.9)

9 (8.1)

47 (68.1)

2 (8.7)

1 (25.0)

 

LPA1

<0.001

 Negative

292 (53.6)

169 (50.0)

73 (65.8)

44 (63.8)

5 (21.7)

1 (25.0)

 

 Positive

253 (46.4)

169 (50.0)

38 (34.2)

25 (36.2)

18 (78.3)

3 (75.0)

 

LPA1 (S)

0.051

 Negative

530 (97.2)

323 (95.6)

111 (100.0)

69 (100.0)

23 (100.0)

4 (100.0)

 

 Positive

15 (2.8)

15 (4.4)

0 (0.0)

0 (0.0)

0 (0.0)

0 (0.0)

 

LPA2

<0.001

 Negative

365 (67.0)

191 (56.5)

85 (76.6)

69 (100.0)

16 (69.6)

4 (100.0)

 

 Positive

180 (33.0)

147 (43.5)

26 (23.4)

0 (0.0)

7 (30.4)

0 (0.0)

 

LPA3

<0.001

 Negative

189 (34.7)

56 (16.6)

52 (46.8)

67 (97.1)

10 (43.5)

4 (100.0)

 

 Positive

356 (65.3)

282 (83.4)

59 (53.2)

2 (2.9)

13 (56.5)

0 (0.0)

 
  1. Italic values represent significance of p-value (p < 0.05)
  2. PTC papillary thyroid carcinoma, FC follicular carcinoma, MC medullary carcinoma, PDC poorly differentiated carcinoma, AC anaplastic carcinoma