Fig. 4
From: CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation
Palbociclib suppression of PCA in vivo. Mouse ear skin (N = 5/group) was sensitized with anti-DNP IgE, treated (or not) with palbociclib, and injected with 20 μg DNP-HSA containing 1% Evans blue as described in detail in “Materials and methods”. Ketotifen treatment was as positive control. a Representative images of PCA mouse ears. b Representative photomicrographs of PCA ear tissue sections. Palbociclib reverses PCA-induced ear thickening (c) and PCA-induced increases in Evans Blue OD620nm. Means ± SDs of 3 independent experiments are shown; *p < 0.05, **p < 0.01 vs. control