Fig. 4

SP-8356 reduces MMP-9 expression and enhances SM-MHC. a Representative image of MMP-9 expression. Vehicle (n = 9), rosuvastatin (n = 6) and SP-8356 (n = 9). The nuclei were stained with DAPI. Scale bars, 100 μm. Magnification, × 100. b Quantification of MMP-9 expression. Data are presented as box plot ± range. ^*p < 0.05. c Representative image of SM-MHC expression. Vehicle (n = 9), rosuvastatin (n = 6) and SP-8356 (n = 9). The nuclei were stained with DAPI. Scale bars, 100 µm. Magnification, × 100. d Quantification of SM-MHC expression. Data are presented as box plot ± range. ^**p < 0.01, ^***p < 0.001