Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 2 | Journal of Translational Medicine

Fig. 2

From: A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation

Fig. 2

SP-8356 enhances the contractile phenotype expression and attenuates CD147-stimulated matrix metalloproteinase-9 (MMP-9) activation in vascular smooth muscle cells (VSMCs) and CD147-induced VSMC migration. a Representative images of immunocytochemistry and b quantitative analysis of relative smooth muscle myosin heavy chain (SM-MHC) expression. Scale bar, 100 μm. Magnification, × 100. Data are presented as the mean ± SD of three independent experiments. ### p < 0.001 vs. control without CD147 treatment. *p < 0.05, ***p < 0.001 vs. CD147 treatment alone. c Representative images of gelatin zymography and quantitative analysis of active MMP-9 level. Data are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001 vs. control. d Representative image of VSMC migration and quantitative analysis. Scale bar, 100 μm. Magnification, × 100. Data are presented as the mean ± SD of three independent experiments. ## p < 0.01 vs. control without CD147 stimulation. *p < 0.05, **p < 0.01, ***p < 0.001 vs. CD147 stimulation alone

Back to article page