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Fig. 6 | Journal of Translational Medicine

Fig. 6

From: Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression

Fig. 6

Effect of valsartan on p47phox phosphorylation in cardiomyocytes. After isolation, neonatal mouse cardiomyocytes were cultured in normal media with valsartan (1 μM) or vehicle in the Rotary Cell Culture System to simulate microgravity. Twenty-four hours later, western blot was performed to analyze the protein levels of p47phox (Ser345) in cardiomyocytes. a A representative western blot from 3 different cell cultures for phosphorylated p47phox and total p47 phox. b The quantitation for phosphorylated p47phox relative to total p47 phox. Data are mean ± SD, n = 3 in each group. *P < 0.05 vs. Sham + Vehicle and P < 0.05 vs. simulated microgravity + Vehicle

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