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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Overinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss

Fig. 1

Coexistence of GJB2 and TMPRSS3 pathogenic variants in normal hearing individuals supports lack of interactions between the two genes. a–c Pedigrees of the analyzed families. Probands are marked with an arrow. Black symbols indicate individuals affected with HL and open symbols indicate unaffected individuals. Red rectangles mark normal hearing individuals being double heterozygous for GJB2 and TMPRSS3 pathogenic variants. d Map of GJB2 and TMPRSS3 interactions according to STRING v.10.5 database. Round symbols indicate different genes. Interactions between genes are represented by color lines described in the legend

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Journal of Translational Medicine

ISSN: 1479-5876

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