Skip to main content

Table 3 Routes of administration and dose of injected SVF cells loaded with ACAM2000

From: First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells

Patient

ID

Route of administration and dose (SVF cell numbers)

I.V.

I.T.

I.P.

Total

1

2.5 × 106

  

2.5 × 106

3

1.4 × 106

1.6 × 106

 

3 × 106

4

3 × 106

  

3 × 106

5

3 × 106

3 × 106

 

6 × 106

8

4.6 × 106

2.4 × 106

 

7 × 106

10

1.2 × 107

6 × 106

 

1.8 × 107

14

1.5 × 106

 

1.5 × 106

3 × 106

15

3.1 × 106

4.8 × 105

 

3.6 × 106

18

3 × 106

  

3 × 106

21

2 × 106

1 × 106

 

3 × 106

22

1 × 106

2 × 106

 

3 × 106

23

3 × 106

 

3.6 × 106

6.6 × 106

24

6.6 × 106

 

6.6 × 106

1.3 × 107

25

1 × 106

2 × 106

 

3 × 106

26

2.1 × 106

9 × 105

 

3 × 106

27

2.1 × 106

9 × 105

 

3 × 106

28

2.1 × 106

9 × 105

 

3 × 106

29

3 × 106

  

3 × 106

30

8.4 × 105

5.6 × 105

 

1.4 × 106

31

7.5 × 105

6.5 × 105

 

1.4 × 106

32

7 × 105

7 × 105

 

1.4 × 106

33

6.5 × 105

5.4 × 105

2.2 × 105

1.4 × 106

34

3 × 106

  

3 × 106

35

7 × 105

7 × 105

 

1.4 × 106

36

1.4 × 106

  

1.4 × 106

47

 

5 × 106

 

5 × 106

  1. Patients’ SVF cells were isolated and incubated with ACAM2000 at a ratio of 1:1 (MOI 1) before the I.V., I.T. and I.P. injections