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Fig. 5 | Journal of Translational Medicine

Fig. 5

From: Identifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data

Fig. 5

Molecular characterization of subpathway signatures. a Dot plot of scores and P values from signet for each of 46 subpathway signatures associated with the responses of different drugs, with y-axis representing entire pathways in KEGG where subpathways are located in. Each node represents the subpathway derived from entire pathway in corresponding dataset. The node size indicates the score of subpathway. Color intensity of node corresponds to negative natural logarithm of P-value, and redder represents the more statistically significant. bg Structure visualization of several subpathway signatures. The rectangle symbolizing gene is divided into three parts, representing left to right: CNV, gene expression, methylation. The number and color intensity of subrectangle correspond to correlation degree of gene with drug response estimated by univariate logistic regression model. Red depicts positive and blue depicts negative correlation

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