Fig. 3
Expression of CCL20 and IL-17A were higher and closely related in sera and tumor tissues of CRC patients. a Evaluation of the expression of CCL20 and IL-17A in sera from 112 CRC patients, 59 HD, 52 colitis and 40 colorectal adenoma patients. Student’s t test was used. b The expression of serum CCL20 and IL-17A in different stage. Student’s t test was used. c Correlation between serum levels of CCL20 and IL-17A in CRC patients. Spearman correlation coefficient was calculated. d Immunohistochemical staining of CCL20 and IL-17A in paired adjacent normal and tumor tissues from one case. Immune reactivity score (IRS) was evaluated in paired adjacent normal and tumor tissues. e IRS was evaluated in different stage. f Correlation between protein levels of CCL20 and IL-17A in tumor tissues from CRC patients and correlation between mRNA levels of CCL20 and IL-17A from GEO and TCGA databases (*p < 0.05; **p < 0.01; ***p < 0.001)