Table 3 Assessment of fasting on plasma pro-inflammatory biomarkers and their evolution during post-fasting phase (n = 78)
| Â | Crude data analysis | Repeated measures logistic regression and generalized least squares random-effects model | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
All | Young (20–30 years) | Adult-to-elderly (≥ 52 years) | |||||||||||
Diff.1 (% ≥ cut-off value) or mean (s.d.) | Crude coeff.2 | 95% CI3 | Adjusted Coeff.4 | 95% CI3 | Crude coeff.2 | 95% CI3 | Adjusted Coeff.4 | 95% CI3 | Crude coeff.2 | 95% CI3 | Adjusted Coeff.4 | 95% CI3 | |
IL-6 | |||||||||||||
P5 = 0.77 | P6 = 0.091 | P7 = 0.074 | P6 = 0.54 | P7 = 0.45 | P6 = 0.10 | P7 = 0.075 | |||||||
Pre-fasting | – | 1 |  | 1 |  | 1 |  | 1 |  | 1 |  | 1 |  |
Fasting | + 15.4 | 0.64 | − 0.03 to 1.30 | + 0.77 | 0.06 to 1.49 | + 0.54 | − 0.42 to 1.51 | + 0.65 | − 0.41 to 1.71 | + 0.74 | − 0.19 to + 1.66 | + 0.89 | − 0.17 to 1.95 |
Post-Fasting | + 15.4 | 0.63 | − 0.03 to 1.30 | +0.58 | − 0.11 to 1.29 | + 0.32 | − 0.64 to 1.29 | + 0.14 | − 0.91 to 1.17 | + 0.98 | 0.02 to 1.94 | + 1.11 | 0.05 to 2.18 |
|  | TNF-α | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P5= 0.003 | P6 = 0.0029 | P7 = 0089 | P6 = 0.038 | P7 = 0.044 | P6 = 0.0039 | P7 = 0.0021 | |||||||
Pre-fasting | – | 1 |  | 1 |  | 1 |  | 1 |  | 1 |  | 1 |  |
Fasting | − 26.3 | − 1.17 | − 1.85 to − 0.50 | − 1.16 | − 1.91 to − 0.42 | − 1.06 | − 2.09 to − 0.02 | − 1.03 | − 2.15 to 0.09 | − 1.27 | − 2.19 to − 0.35 | − 1.56 | − 2.61 to − 0.52 |
Post-fasting | − 9.6 | − 0.39 | − 1.01 to 0.23 | − 0.35 | − 1.03 to 0.33 | − 1.22 | − 2.30 to − 0.16 | − 1.35 | − 2.52 to 0.18 | + 0.20 | − 0.65 to 1.05 | + 0.50 | − 0.44 to1.44 |
| Â | C-reactive protein | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
P5 < 0.0001 | P6 < 0.0001 | P7 < 0.0001 | P6 < 0.0001 | P7 < 0.0001 | P6 < 0.0001 | P7 < 0.0001 | |||||||
Pre-fasting | 3.03 (0.84) | 1 | Â | 1 | Â | 1 | Â | 1 | Â | 1 | Â | 1 | Â |
Fasting | 1.89 (0.25) | − 1.14 | − 1.30 to − 0.97 | − 1.14 | − 1.31 to − 0.96 | − 0.62 | − 0.76 to −0.47 | − 0.65 | − 0.81 to − 0.50 | − 1.61 | − 1.83 to − 1.39 | − 1.62 | − 1.88 to − 1.36 |
Post-fasting | 3.14 (0.84) | + 0.11 | − 0.05 – 0.27 | + 0.11 | − 0.07 to 0.28 | + 0.11 | − 0.03 to 0.25 | + 0.15 | − 0.01 to 0.31 | + 0.11 | − 0.11 to 0.33 | + 0.14 | − 0.11 to 0.38 |