Journal of Translational Medicine

Table 2 Secretome

From: In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia

	CFU-F medium		EGM-2 medium		p^b
	CFU-F medium^a	MSCs culture supernates	EGM-2 medium^a	S-MSCs culture supernates	p^b
VEGF-A (pg/mg proteins)	∅	272 [182–478]	180	464 [288-627]	NS^c
FGF2 (pg/mg proteins)	∅	∅	101	7 [4–16]	0.003
EGF (pg/mg proteins)	∅	∅	5056	1643 [736–3710]	0.003
IGF-1 (pg/mg proteins)	332	154 [35–308]	826	319 [150–452]	0.003^c
PDGF-AA (pg/mg proteins)	∅	0.9 [nd–13]	∅	20 [3–60]	0.003
Angio-1 (pg/mg proteins)	∅	159 [91–377]	∅	899 [371–2234]	0.003
LIF (pg/mg proteins)	∅	49 [31–82]	∅	149 [99–283]	0.003
CXCL12 (pg/mg proteins)	∅	3475 [1418–6987]	∅	∅	0.003
IL-6 (pg/mg proteins)	∅	741 [479–1202]	∅	63 [4–127]	0.003
HGF (pg/mg proteins)	∅	17 [1–44]	∅	4 [nd–159]	NS

A set of ten growth factors [VEGF-A, EGF, FGF2, IGF-1, Angio-1, IL-6, HGF, PDGF-AA, LIF, SDF-1 (or CXCL12)] was measured in the MSCs (n = 7) and S-MSCs (n = 7) culture supernates at day 28 and in CFU-F and EGM-2 media
NS not significant, ∅ undetectable
^aCell-free media
^bComparison of MSCs culture supernates versus S-MSCs culture supernates
^cComparison after subtraction of basal medium content

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ISSN: 1479-5876

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