Table 2 Co-expression of exhaustion markers
From: Large-scale expansion and characterization of CD3+ T-cells in the Quantum® Cell Expansion System
T-cell source | Percentage of T-cells co-expressing LAG-3, PD-1 and Tim-3 | |||||||
|---|---|---|---|---|---|---|---|---|
CD4+ T-cells | CD8+ T-cells | |||||||
LAG-3/PD-1/Tim-3 | LAG-3/PD-1 | LAG3/Tim-3 | PD-1/Tim-3 | LAG-3/PD-1/Tim-3 | LAG-3/PD-1 | LAG-3/Tim-3 | PD-1/Tim-3 | |
Pre | 0 | 0 | 0.1 (0.07–0.23) | 0 | 0.1 (0.03–0.21) | 0 | 0.1 (0.05–0.29) | 0.1 (0.03–0.21) |
LS | 0.1 (0.07–0.20) | 0 | 0 | 7.7 (1.66–15.30) | 0.2 (0.01–0.61) | 0 | 0.2 (0.12–0.43) | 2.0 (1.34–3.44) |
HS | 0.2 (0.09–0.31) | 0 | 0.1 (0.10–0.21) | 6.8 (1.42–10.00) | 0.3 (0.14–0.40) | 0 | 0.4 (0.22–0.64) | 1.3 (0.90–1.89) |