Skip to main content

Table 2 Co-expression of exhaustion markers

From: Large-scale expansion and characterization of CD3+ T-cells in the Quantum® Cell Expansion System

T-cell source Percentage of T-cells co-expressing LAG-3, PD-1 and Tim-3
CD4+ T-cells CD8+ T-cells
LAG-3/PD-1/Tim-3 LAG-3/PD-1 LAG3/Tim-3 PD-1/Tim-3 LAG-3/PD-1/Tim-3 LAG-3/PD-1 LAG-3/Tim-3 PD-1/Tim-3
Pre 0 0 0.1 (0.07–0.23) 0 0.1 (0.03–0.21) 0 0.1 (0.05–0.29) 0.1 (0.03–0.21)
LS 0.1 (0.07–0.20) 0 0 7.7 (1.66–15.30) 0.2 (0.01–0.61) 0 0.2 (0.12–0.43) 2.0 (1.34–3.44)
HS 0.2 (0.09–0.31) 0 0.1 (0.10–0.21) 6.8 (1.42–10.00) 0.3 (0.14–0.40) 0 0.4 (0.22–0.64) 1.3 (0.90–1.89)
  1. Mean percent and ranges (parentheses) for T-cells from 5 donors are shown. Values less than 0.1% are reported as 0
  2. PRE pre-expansion PBMCs, LS low seed, HS high seed