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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: The epigenome as a putative target for skin repair: the HDAC inhibitor Trichostatin A modulates myeloid progenitor plasticity and behavior and improves wound healing

Fig. 1

HDAC activity is necessary for myeloid differentiation. Non-adherent bone marrow cells were treated with GM-CSF (10 ng/ml) and/or iHDAC (10 nM TSA) and analyzed after 24, 72 and 7 days of culture. b Region P2 for exclusion of dead cells and cell debris. Phenotypic analysis of hematopoietic cells by two classical markers of the myeloid lineage, CD11b and Ly6C, at 24 h (ac) and 7 days (df). Histogram of Ly6C (gi) and CD11b (jl) subsets upon 7 days in culture. n = 3 animals per group; Data are mean ± SD. Statistically significant differences p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.001 by the two-way repeated measures ANOVA followed by the test of Bonferroni to correct the value of p

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