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Fig. 1 | Journal of Translational Medicine

Fig. 1

From: Meeting abstracts from the 9th International Conference on cGMP: Generators, Effectors and Therapeutic Implications

Fig. 1

Reduced nocifensive behavior of a conditional GC-B mouse mutant lacking sensory axon bifurcation. a Dorsal views of spinal cords from GC-Bfl/fl;Thy1YFPH and GC-Bfl/fl;Wnt1Cre;Thy1YFPH show a loss of axon bifurcation in the conditional mutant that persisted at mature stages (P15). Scale bar, 250 μm. GC-Bfl/fl;Wnt1Cre conditional mouse mutants show a decrease in (b) thermal heat pain assessed on a 50 °C, 52 °C, and 54 °C hot plate (n = 15–16; *p < 0.05), c thermosensation measured by the Hargreaves’ method (Plantar test) at 3 consecutive days (n = 8; *p < 0.05 and **p < 0.01) and chemical pain response to hindpaw injection of e 5 μg capsaicin (n = 9) or f 0.5% formalin (n = 5) *p < 0.05

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