Fig. 1

sGC agonists are effective as formoterol in bronchodilating human lung slices. Small airways in lung slices were contracted with carbachol followed by addition of the indicated compounds and image collection and processing to determine bronchiole lumen area, expressed as % compared to baseline. a Concentration response curves (100 pM–30 µM) toward formoterol, BAY 41, or BAY 60. b Maximal amount of bronchodilation induced by each bronchodilator. Data derived from n = 15 donor lungs, showing mean ± SEM with 18–27 slices tested per condition