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Fig. 3 | Journal of Translational Medicine

Fig. 3

From: Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Fig. 3

Protective efficacy of intranodal immunizations of NP mRNA against heterologous challenge. BALB/c mice were immunized twice with 17 µg of NP or control mRNA (Ctrl) or 50 µg of HA mRNA with 1 week between immunizations. 8 weeks after boost immunizations, mice were infected with 1xLD50 of influenza A H1N1 PR8. a Determination of viral titers in the BALF isolated on day 6 after infection. Results are shown as median ± IQR and each symbol represents one mouse (n = 6 per group). Differences were determined by one-way ANOVA. b Body weight changes after challenge expressed as mean ± SEM. Upon reaching the human-endpoint, mice were excluded from the data. c Survival of mice after challenge (n = 6 for NP and HA groups, n = 5 for control mice)

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