Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

Table 1 The basic information of 10 PDX models

Code	Gender	Age	Ulceration	Anatomic site	Stage	CDK4	CCND1	P16 ^INK4a	KIT	BRAF	NRAS
PDX-001	M	49	Yes	1	IV	Normal	Normal	Normal	WT	WT	WT
PDX-002	M	57	Yes	4	IV	Normal	Normal	Normal	W557R	WT	WT
PDX-003	F	78	Yes	5	II	Gain	Gain	Loss	WT	WT	WT
PDX-004	F	43	Yes	5	III	Gain	Gain	Loss	L576P	WT	WT
PDX-005	F	57	Yes	5	II	Gain	Gain	Loss	WT	WT	WT
PDX-006	M	58	Yes	3	I	Gain	Gain	Loss	WT	WT	WT
PDX-007	F	71	Yes	2	II	Gain	Gain	Normal	WT	WT	WT
PDX-008	F	65	No	1	II	Gain	Gain	Normal	WT	WT	G12C
PDX-009	F	69	Yes	1	II	Normal	Gain	Loss	WT	WT	Q61L
PDX-010	M	55	Yes	2	II	Normal	Gain	Normal	WT	WT	WT

F female, M male, WT wild type
a: Anatomic site: 1 = nasopharynx; 2 = oral cavities; 3 = esophagus; 4 = anorectum; 5 = genitourinary

ISSN: 1479-5876