Fig. 2

Sensitivity of PDX models containing CDK4 aberrations to CDK4/6 inhibitors in vivo. When the tumor size reached approximately 600 mm³, mice (n = 4 per group) were treated with buffer control or inhibitors daily. Tumor volume was evaluated as % of the tumor volume on day 0 and presented as mean ± SD. The comparison of the growth curves was done with the repeated measure variance analysis. ns no significances; **P < 0.01; ***P < 0.001